Middle linebackers are the quarterbacks of the defense, the nerve center of a stop-unit. Many of the game’s greatest players have been the man in the middle who called the shots in the huddle before turning into tackling machines and splash-playmakers from sideline-to-sideline once the ball was snapped. Keeping all aspects of the job in mind, we rank the top 25 greatest middle linebackers in NFL history.

Two divisional foes coming off drastically different Week 6 contests will meet on Thursday Night Football, when the San Francisco 49ers host the Seattle Seahawks at 8:20 p.m. EST on the NFL Network. The 49ers were surprisingly “out-physicaled” against the Giants last week, losing the NFC Championship Game rematch 26-3 at home.
Some of the national attention will be on the two coaches when the San Francisco 49ers host the Detroit Lions Sunday night at 8:20pm EST on NBC, but the real story is a solid NFC matchup between two postseason teams with high goals for this season.
The marquee matchup of the NFL’s opening weekend will take place at historic Lambeau Field, with the Green Bay Packers hosting the San Francisco 49ers at 4:25pm EST on Fox. These two NFC stalwarts combined for 28 regular-season wins in 2011, and both clubs have Super Bowl expectations in 2012.