The NFC West could be decided when the San Francisco 49ers take on the Seattle Seahawks at 8:20 p.m ET tonight on NBC. A win would clinch a second straight division title for the 49ers (10-3-1), while handing the Seahawks (9-5) their first home loss of the season. The Seahawks are currently seeded fifth in the NFC playoff bracket, but four teams are right behind them at 8-6, so they still have work to do to secure their postseason berth.
The marquee matchup of the NFL’s opening weekend will take place at historic Lambeau Field, with the Green Bay Packers hosting the San Francisco 49ers at 4:25pm EST on Fox. These two NFC stalwarts combined for 28 regular-season wins in 2011, and both clubs have Super Bowl expectations in 2012.