Ball State’s MiQuale Lewis has been one of the biggest surprises at the running back spot this year. The junior suffered season-ending injuries in his first two years but has remained healthy throughout 2008 and is approaching the 1,600-yard mark on the ground. Lewis has rushed for 20 touchdowns and at least one in every game but two. As with all positions in Week 15, they are thin in fantasy options. Lewis takes on a Buffalo defense giving up nearly 160 rushing yards per game and is the top option for owners looking for a running back.
Virginia Tech-Boston College should be a defensive battle and fantasy owners should lower their expectations for Darren Evans, Montel Harris and Josh Haden. Both teams are have been stingy against the run and all three backs could struggle to get 100 yards.
| Rank | Player | Team | Opponent |
| 1 | MiQuale Lewis | Ball State | Buffalo |
| 2 | James Starks | Buffalo | Ball State |
| 3 | Donald Brown | Connecticut | Pitt |
| 4 | LeSean McCoy | Pitt | at Connecticut |
| 5 | Jahvid Best | California | Washington |
| 6 | Tyrell Fenroy | UL Lafayette | MTSU |
| 7 | DeMarco Murray | Oklahoma | Missouri |
| 8 | Chris Brown | Oklahoma | Missouri |
| 9 | DuJuan Harris | Troy | Arkansas STate |
| 10 | Tarrion Adams | Tulsa | ECU |
| 11 | Reggie Arnold | Arkansas State | at Troy |
| 12 | Phillip Tanner | MTSU | at UL Lafayette |
| 13 | Glen Coffee | Alabama | Florida |
| 14 | Derrick Washington | Missouri | Oklahoma |
| 15 | Eric Kettani | Navy | Army |
| 16 | Collin Mooney | Army | Navy |
| 17 | Brandon Simmons | ECU | at Tulsa |
| 18 | Joe McKnight | USC | at UCLA |
| 19 | Stafon Johnson | USC | at UCLA |
| 20 | C.J. Gable | USC | at UCLA |
| 21 | Keola Antolin | Arizona | Arizona State |
| 22 | Nic Grigsby | Arizona | Arizona State |
| 23 | Darriet Perry | FIU | WKU |
| 24 | Charles Clay | Tulsa | ECU |
| 25 | Jacob Ramsey | Cincinnati | at Hawaii |
| 26 | John Goebel | Cincinnati | at Hawaii |
| 27 | Noel Devine | WVU | South Florida |
| 28 | Darren Evans | Va. Tech | Boston College |
| 29 | Montel Harris | Boston College | Virginia Tech |
| 30 | Victor Anderson | Louisville | at Rutgers |
| 31 | Jeff Demps | Florida | Alabama |
| 32 | Chris Rainey | Florida | Alabama |
| 33 | Shane Vereen | California | Washington |
| 34 | Mark Ingram | Alabama | Florida |
| 35 | Keegan Herring | Arizona State | at Arizona |
| 36 | Norman Whitley | ECU | at Tulsa |
| 37 | Mike Ford | South Florida | at WVU |
| 38 | Benjamin Williams | South Florida | at WVU |
| 39 | Kordell Young | Rutgers | Louisville |
| 40 | Joe Martinek | Rutgers | Louisville |
| 41 | Shun White | Navy | Army |
| 42 | Josh Haden | Boston College | Virginia Tech |
| 43 | Brock Bolen | Louisville | at Rutgers |
| 44 | Julian Reams | FIU | WKU |
| 45 | Derek Lawson | Arkansas State | at Troy |
| 46 | Kahlil Bell | UCLA | USC |
| 47 | Emmanuel Moody | Florida | Alabama |
| 48 | Daniel Libre | Hawaii | Cincinnati |
| 49 | Tyrell Hayden | WKU | at FIU |
| 50 | Terrance Dailey | Washington | at California |
| 51 | Willie Griffin | Washington | at California |
| 52 | Jamar Taylor | South Florida | at WVU |
| 53 | Mark Rodgers | WVU | South Florida |

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