San Francisco 49ers vs. New England Patriots Preview and Prediction

Two of the NFL’s best meet as the 49ers try to end the Patriots’ seven-game winning streak

The San Francisco 49ers and New England Patriots face off tonight at 8:20 p.m. ET on NBC in what could potentially be a preview of Super Bowl XLVII. The 49ers (9-3-1) are trying to hold Seattle off for the top spot in the NFC West, while the Patriots (10-3) could potentially knock Houston from the top of the standings in the AFC. This also is a matchup of one of the league’s top defenses in San Francisco trying to slow down a New England offense that’s been lighting up the scoreboard most of the season.

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NFL Picks Against the Spread: Week 15

Aaron Rodgers and the Green Bay Packers will take on the Chicago Bears in the NFL's oldest rivalry.

A betting preview of every game (against the spread) on Sunday and Monday in Week 15.


Locks of the Week
Rematches of heated rivalries, a neutral site home game in Canada and a nine-game losing streak all look good to go this week.


Packers (-2.5) at Bears

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5 Injuries That Altered the NFL Season

If they stayed healthy, who knows what could have been

When Robert Griffin III limped off the field last Sunday, it figured to be a devastating injury for the Washington Redskins. He’s their most dynamic player and the reason they’ve made a race out of the NFC East. His loss would’ve changed the outlook of the entire division.

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2012 NFL Picks, Every Game: Week 15

Aldon Smith and the San Francisco 49ers travel cross-country to take on the New England Patriots.

NFL Week 15 previews and predictions for every game on the schedule:

 

Bengals (7-6) at Eagles (4-9)
Philadelphia ended its eight-game losing streak — the team’s longest run of futility in 42 years — on a last-second TD at Tampa Bay. Now the Eagles look to end a four-game losing streak at home. If they do, the game will be a close one; Philly’s four wins this season have come by a combined six points.
Bengals by 3

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NFL Power Rankings Going Into Week 15

Big Ben Roethlisberger returned to the field, but the Pittsburgh Steelers struggled this week.

Athlon Sports' weekly rankings of NFL teams. The New England Patriots have moved into the top spot after knocking out previous the No. 1 Houston Texans, while no team is playing worse than the recently humiliated Arizona Cardinals.

Here are our NFL Power Rankings following Week 14 of the season:


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NFL Power Rankings Going Into Week 14

The Pittsburgh Steelers defeated the Baltimore Ravens despite missing Ben Roethlisberger.

Athlon Sports' weekly rankings of NFL teams. The Houston Texans remain the top team, while the Jacksonville Jaguars moved back to the bottom this week.

Here are our NFL Power Rankings following Week 13 of the season:

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NFL Picks Against the Spread: Week 13

RG3 will look to recreate his Thanksgiving magic in his Monday Night Football debut.

A betting preview of every game (against the spread) on Sunday and Monday in Week 13.


Locks of the Week
Three quarterbacks with chips on their shoulders take on two of the most inconsistent teams in the league and the worst squad.

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2012 NFL Picks, Every Game: Week 13

Giants two-time Super Bowl champ Eli Manning takes on Redskins rookie phenom Robert Griffin III.

NFL Week 13 previews and predictions for every game on the schedule:

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NFL Power Rankings Going Into Week 13

The Houston Texans remain the top-ranked team after their overtime win on Thanksgiving Day.

Athlon Sports' weekly rankings of NFL teams — from the best, one-loss Houston Texans, to the worst, the autograph-seeking one-win Kansas City Chiefs.

Here are our NFL Power Rankings following Week 12 of the season:

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7 Amazing Stats from NFL Sunday: Week 12

Highlighting the most important, intriguing and bizarre stats of the weekend.

NFL football is the greatest reality TV program of all time. The Giants and Colts made sure of that back in 1958. Each NFL fall weekend is a completely new and original experience for every player, fan and coach alike. New stories, new personalities, new winners and new losers. And new statistics.

Here are the most important, most intriguing and most bizarre statistics from Week 12 of NFL play:

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