The Green Bay Packers and San Francisco 49ers will get together for the second time this season when Saturday’s NFC Divisional playoff game kicks off at 8 p.m. ET on FOX. The champions of the NFC North and West divisions opened the season against each other, but the stakes aren’t the only things that have changed for this matchup.

The Minnesota Vikings and Green Bay Packers will face off for the second time in less than a week when their NFC Wild Card showdown kicks off on Saturday at 8 p.m. ET on NBC. The Vikings (10-6) beat the Packers (11-5) last Sunday 37-34 in Minneapolis to secure their playoff berth, while costing the NFC North champions a first-round bye in the process. Even though these teams have played each other 104 times, this marks just the second postseason matchup. Minnesota beat Green Bay 31-17 in an NFC Wild Card game at Lambeau Field on Jan. 9, 2005.

The Green Bay Packers and Minnesota Vikings each have something to play for when the long-time NFC North rivals meet up at 4:25 p.m. ET this afternoon on FOX. For the Vikings (9-6) it’s win and they are in the playoffs for the first time since 2009, while the Packers (11-4) can earn a coveted first-round bye with a second win over their divisional foe this month. If the Vikings fall to the Packers for a sixth straight time, they will need Chicago, Dallas and the New York Giants to all lose to extend their season by at least one more game.

The Detroit Lions will try and play spoiler when they take on the Green Bay Packers tonight at 8:20 p.m. ET on NBC. The Lions (4-8) are looking to end a four-game losing streak and do something they haven’t done in more than 20 years – win at Lambeau Field. The Packers (8-4) are aiming to stay atop the NFC North standings by beating the Lions for the second time in less than a month.

Green Bay wide receiver Greg Jennings is officially listed as Doubtful for Thursday night’s game against Chicago. The Packer, who is dealing with a groin injury, is said to have a “50-50” chance of playing in this NFC North clash against the Bears.

The Thursday night game will feature the NFL’s oldest rivalry, with the Green Bay Packers hosting the Chicago Bears at 8:20 p.m. EST on the NFL Network. These two NFC North foes had very different experiences in their openers, as the Bears easily handled the Colts while the Packers ran into the juggernaut defense of the 49ers — losing 30-22 at home.

The marquee matchup of the NFL’s opening weekend will take place at historic Lambeau Field, with the Green Bay Packers hosting the San Francisco 49ers at 4:25pm EST on Fox. These two NFC stalwarts combined for 28 regular-season wins in 2011, and both clubs have Super Bowl expectations in 2012.

There is a long, long way to go for the Green Bay Packers – probably longer than they even realize. That’s a lesson that was learned the hard way by so many previously unbeaten teams. Even the teams that look unbeatable, the way the Packers do right now, can be beaten when they least expect it.

Just ask the 2007 New England Patriots, who were once 2 ½ minutes away from finishing 19-0.

The playoffs start for some fantasy football leagues in Week 13, for many more this is the final push to try and secure a spot before the playoffs start. This late into the season, there’s not a whole lot to trust on the waiver wire; they wouldn’t be on there if you could.